【职称】副教授，硕士生导师
【学位/学历】
医学博士/研究生
【学习工作经历】
2024/7-至今 91吃瓜
91吃瓜
副教授
2022/7-2024/7 美国范德堡大学医学中心 博士后
2021/4-2023/3 西湖大学 博士后
2015/9-2020/6 哈尔滨医科大学 流行病与卫生统计学 博士（硕博连读）
【研究方向及兴趣】
多组学数据与系统流行病学研究:（1）利用包含代谢组学、微生物组学及蛋白质组学等在内的人群多组学数据，结合新型的统计分析方法（机器学习模型），识别心血管代谢疾病（如糖尿病、肥胖、代谢综合征、冠心病等）新的分子标志物，建立相应的预测模型，并探究潜在分子机制；（2）利用多组学数据，探究营养和生活方式因素与心血管代谢疾病之间关联的潜在通路和分子机制，识别出响应人群，促进心血管代谢疾病的精准化预防。
【课题组招生】
欢迎预防医学、统计学、生物信息学、基础医学等相关学科背景的同学报考硕士研究生（流行病与卫生统计学学术型硕士）；同时欢迎本科生加入课题组进行科研训练（邮件联系：[email protected]）。
【论文代表作（近五年）】
（#第一作者，*通讯作者）
1. Kui Deng, Lei Wang, Sang Minh Nguyen, Martha J. Shrubsole, Qiuyin Cai, Loren Lipworth, Deepak K. Gupta, Wei Zheng, Xiao-Ou Shu, Danxia Yu*. A dietary pattern promoting gut sulfur metabolism is associated with increased mortality and altered circulating metabolites in low-income American adults. eBioMedicine. 2025 Apr 5;115:105690.
2. Kui Deng#, Luqi Shen#, Zhangzhi Xue#, Bang-Yan Li#, Jun Tang, Hui Zhao, Fengzhe Xu, Zelei Miao, Xue Cai, Wei Hu, Yuanqing Fu, Zengliang Jiang, Xinxiu Liang, Congmei Xiao, Menglei Shuai, Wanglong Gou, Liang Yue, Yuting Xie, Ting-Yu Sun, Tiannan Guo, Yu-Ming Chen*, Ju-Sheng Zheng*. Association of the EAT-Lancet diet, serial measures of serum proteome and gut microbiome, and cardiometabolic health: a prospective study of Chinese middle-aged and elderly adults. The American Journal of Clinical Nutrition. 2025 Mar;121(3):567-579.
3. Kui Deng, Deepak K. Gupta, Xiao-Ou Shu, Loren Lipworth, Wei Zheng, Hui Cai, Qiuyin Cai, Danxia Yu*. Circulating metabolite profiles and risk of coronary heart disease among racially and geographically diverse populations. Circulation Genomic and Precision Medicine. 2024 Jul 1:e004437.
4. Kui Deng, Meng Xu, Melis Sahinoz, Qiuyin Cai, Martha J. Shrubsole, Loren Lipworth, Deepak K. Gupta, Debra D. Dixon, Wei Zheng, Ravi Shah, Danxia Yu*. Associations of neighborhood sociodemographic environment with mortality and circulating metabolites among low-income Black and White Americans. BMC Medicine. 2024 Jun 18;22(1):249.
5. Kui Deng#, Xiong-Fei Pan#, Markus W Voehler, Qiuyin Cai, Hui Cai, Xiao-Ou Shu, Deepak K. Gupta, Loren Lipworth, Wei Zheng, Danxia Yu*. Blood lipids, lipoproteins, and apolipoproteins with risk of coronary heart disease: a prospective study among multi-racial populations. Journal of the American Heart Association. 2024 May 21;13(10):e034364.
6. Kui Deng, Deepak K. Gupta, Xiao-Ou Shu, Loren Lipworth, Wei Zheng, Victoria E. Thomas, Hui Cai1, Qiuyin Cai, Thomas J. Wang, Danxia Yu*. Metabolite signature of life’s essential 8 and risk of coronary heart disease among low-income Black and White Americans. Circulation Genomic and Precision Medicine. 2023 Dec;16(6):e004230.
7. Kui Deng#, Jin-Jian Xu#, Luqi Shen#, Hui Zhao, Wanglong Gou, Fengzhe Xu, Yuanqing Fu, Zengliang Jiang, Menglei Shuai, Bang-Yan Li, Wei Hu, Ju-Sheng Zheng*, Yu-Ming Chen*. Comparison of fecal and blood metabolome reveals inconsistent associations of the gut microbiota with cardiometabolic diseases. Nature Communications, 2023, 14(1):571.
8. Wanglong Gou#, Zelei Miao#, Kui Deng#, Ju-Sheng Zheng*. Nutri-microbiome epidemiology, an emerging field to disentangle the interplay between nutrition and microbiome for human health. Protein Cell, 2023 Nov 8;14(11):787-806.
9. Kui Deng, Menglei Shuai, Zheqing Zhang, Zengliang Jiang, Yuanqing Fu, Luqi Shen, Ju-Sheng Zheng*, Yu-ming Chen*. Temporal relationship among adiposity, gut microbiota, and insulin resistance in a longitudinal human cohort. BMC Medicine, 2022, 20(1):171.
10. Kui Deng#, Falin Zhao#, Zhiwei Rong, Lei Cao, Liuchao Zhang, Kang Li*, Yan Hou*, Zheng-Jiang Zhu*. WaveICA 2.0: a novel batch effect removal method for untargeted metabolomics data without using batch information. Metabolomics, 2021, 17(10): 1-8.
11. Kui Deng, Fan Zhang, Qilong Tan, Yue Huang, Wei Song, Zhiwei Rong, Zhengjiang Zhu, Kang Li*, Zhenzi Li*. WaveICA: a novel algorithm to remove batch effects for large-scale untargeted metabolomics data based on wavelet analysis. Analytica Chimica Acta, 2019, 1061: 60-69.
【研究项目】
2024-2027 91吃瓜
引进人才基本启动经费
2023/1-2025/12 国家自然科学基金青年科学基金项目，82204161，30万，主持
2022/6-2023/3 中国博士后科学基金面上资助一等，2022M710131，12万，主持
【参编教材与论著】
营养流行病学数据统计分析方法与应用（人民卫生出版社） 论著 参编
营养与肠道菌群（上海科学技术出版社） 论著 参编
【获奖情况】
2019，中国生物统计2019年学术年会优秀研究生论文一等奖 (中国广州)
2019，博士研究生国家奖学金
【社会兼职】
北美华人营养学会会员
美国心脏协会会员
中国公共卫生管理期刊青年编委
