学位/学历： 
卫生毒理学 医学博士

学术简历： 
【学习经历】
2015.09 – 2020.06 91吃瓜 卫生毒理学 医学博士
2010.09 – 2015.06 91吃瓜 预防医学   医学学士
【工作经历】
2023.12 – 至今   91吃瓜 副教授
2022.07 – 2023.11 91吃瓜 副研究员
2020.07 – 2022.07 91吃瓜 博士后
  
 研究方向：
　　主要从事环境毒理与健康研究，致力于环境污染物的体外评价模型构建、毒效应分子机制和干预措施研究。主持国家自然科学基金项目1项，省部级项目3项，作为骨干参与国家自然科学基金重点项目。以第一/共一作者在Environ Health Perspect、Environ Int、Part Fibre Toxicol、J Hazard Mater、Arch Toxicol、Toxicol Sci等环境毒理学权威期刊发表SCI论文。

论文代表作（#第一作者，*通讯作者）： 
1. Zhang R#, Chen S#, Wang ZW#, Ye LZ, Jiang Y, Li M Jiang XH, Peng H, Guo ZY, Chen LP, Zhang R, Niu YJ, Aschner M, Li DC*, Chen W*. Assessing the effects of nicotinamide mononucleotide supplementation on pulmonary inflammation in male mice subchronically exposed to ambient particulate matter. Environ Health Perspect. 2023 Jul;131(7):77006.
2. Chen S#, Li M#, Zhang R#, Ye LZ, Jiang Y, Jiang XH, Peng H, Wang Z, Guo ZY, Chen LP, Zhang R, Niu YJ, Aschner M, Li DC, Chen W*. Type 1 diabetes and diet-induced obesity predispose C57BL/6J mice to PM2.5-induced lung injury: a comparative study. Part Fibre Toxicol. 2023 Apr 17; 20(1):10.
3. Wang ZW#, Chen S#, Pang YQ#, Ye LZ, Zhang Q, Jiang XH, Zhang R, Li M, Guo ZY, Jiang Y, Li DC, Xing XM, Chen LP, Aschner M*, Chen W*. Morphological alterations in C57BL/6 mouse intestinal organoids as a tool for predicting chemical-induced toxicity. Arch Toxicol. 2023 Apr; 97(4):1133-1146.
4. Zhang Rui#, Chen S#, Chen LP#, Ye LZ, Jiang Y, Peng H, Guo ZY, Li M, Jiang XH, Guo P, Yu DK, Zhang R, Niu YJ, Zhuang Y, Aschner M, Zheng YX, Li DC*, Chen W*. Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure. Part Fibre Toxicol. 2022 Jun 23; 19(1):42.
5. Chen S#, Li DC#, Yu DK, Li M, Ye LZ, Jiang Y, Tang SJ, Zhang R, Xu C, Jiang SY, Wang ZW, Aschner M, Zheng YX, Chen LP*, Chen W*. Determination of tipping point in course of PM2.5 organic extracts-induced malignant transformation by dynamic network biomarkers. J Hazard Mater. 2022 Mar 15; 426:128089.
6. Chen S#, Chen LP#, Ye LZ#, Jiang Y, Li Q, Zhang HY, Zhang R, Li HY, Yu DK, Zhang R, Niu Y, Zhao Q, Liu JH, Ouyang GF, Aschner M, Zheng YX, Zhang LH, Chen W*, Li DC*. PP2A-mTOR-p70S6K/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury. J Hazard Mater. 2022 Feb 15; 424 (Pt C):127624.
7. Chen S, Tang Y, Fang WJ, He TP, Chen X*, Zhang PW*. CoQ10 Promotes Resolution of Necrosis and Liver Regeneration After Acetaminophen-Induced Liver Injury. Toxicol Sci. 2021 Dec 28;185(1):19-27.
8. Zhang PW#, Chen S#, Tang HW, Fang WJ, Chen K, Chen X*. CoQ10 protects against acetaminophen-induced liver injury by enhancing mitophagy. Toxicol Appl Pharmacol. 2021 Jan 1; 410:115355.
9. Chen S#, Li DC#, Wu XN#, Chen LP, Zhang B, Tan YF, Yu DK, Niu Y, Duan HW, Li Q, Chen R, Aschner M, Zheng YX, Chen W*. Application of cell-based biological bioassays for health risk assessment of PM2.5 exposure in three megacities, China. Environ Int. 2020 Jun; 139:105703.
10. Li DC#, Chen S#, Li Q#, Chen LP, Zhang HY, Li HY, Yu DK, Zhang R, Niu YJ, Lu SY, Ye LZ, Zeng XW, Dong GH, Chen R, Aschner M, Zheng YX, Chen W*. Caloric restriction attenuates C57BL/6 J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure. Part Fibre Toxicol. 2020 Jun 5;17(1):22.
11. Guo P#, Chen S#, Li DC, Zhang JM, Luo J, Zhang AH, Yu DK, Michael S Bloom, Chen LP*, Chen W. SFPQ is involved in regulating arsenic-induced oxidative stress by interacting with the miRNA-induced silencing complexes. Environ Pollut. 2020 Jun; 261:114160.
12. Chen S#, Li DC#, Zhang HY#, Yu DK, Chen R, Zhang B, Tan YF, Niu Y, Duan HW, Mai BX, Chen SJ, Yu JZ, Luan TG, Chen LP, Xing XM, Li Q, Xiao YM, Dong GH, Niu YJ, Aschner M, Zhang R, Zheng YX, Chen W*. The development of a cell-based model for the assessment of carcinogenic potential upon long-term PM2.5 exposure. Environ Int. 2019 Oct; 131:104943.

主要承担或参与的课题：
2023.01 – 2025.12 国家自然科学基金青年基金项目 主持人
2023.01 – 2025.12 广东省自然科学基金面上项目   主持人
2024.01 – 2025.12 广州市基础与应用基础研究项目 主持人
2022.01 – 2026.12 国家自然科学基金重点项目     参与人
2020.07 – 2022.06 中国博士后面上项目           主持人

参编教材与论著： 
1. 《现代毒理学》[M]. 人民卫生出版社
2. 《基于毒作用模式的典型环境污染物风险评估》[M]. 91吃瓜 出版社