【个人简历】

郭城，副教授，博士生导师，国家药品监督管理局疫苗及生物制品质量监测与评价重点实验室副主任。博士毕业后先后就职于美国环境保护署以及美国哥伦比亚大学医学院感染与免疫研究中心担任研究员和团队负责人等职务，十余年海外留学工作经历。

多年来聚焦病原检测技术、疫苗及生物制品评价的创新与应用：①发明病原捕获测序与高通量血清学检测技术，使其较传统方法通量提升千倍，检测敏感性提高近百倍，技术达到国际领先水平；②应用新技术在临床或自然场景中开展新发传染病研究，检测出多种传统方法难以识别的新型病原体及相关风险因素，如发现新冠病毒可长期存于患者肠道且与疾病严重程度相关、鉴定出有跨宿主传播风险的新型沙粒病毒等；③针对多种后急性感染综合征,分析病原体感染痕迹并鉴定潜在生物标志物，揭示肠道丁酸盐产生菌在疾病进展中的潜在保护作用及其在早期诊疗中的应用潜力。近年来在Cell Host Microbe，Lancet Gastroenterol等杂志发表论文40余篇，被引用4000余次，获批多项与病原检测相关的美国发明专利。相关科研成果曾被时代杂志、纽约日报、财新新闻等20多家新闻媒体报道。

课题组主页：//lab.chengguo-sysu.cn/

 

【工作经历】
2024/02至今，91吃瓜 ，91吃瓜 ，副教授
2022/10-2024/02，哥伦比亚大学(Columbia University)，91吃瓜 ，感染免疫研究中心生信团队负责人(Head of Bioinformatics)
2016/05-2024/03，哥伦比亚大学，91吃瓜 ，高级生信研究员(Senior Programmer Analyst/Bioinformatics)
2015/01-2016/05，美国国家环境保护署(EPA)，生物信息师(Bioinformatician)

 

【学习经历】
2011/09-2016/10，迈阿密大学(Miami University), 生物信息学，博士
2008/09-2011/06，中国药科大学，药物生物信息学，硕士
2004/09-2008/06，中国药科大学，生命科学基地班，学士

 

【研究生招生与博士后招聘】
博士/硕士研究生 (方向：公共卫生与预防、医学流行病与卫生统计学、公共卫生硕士MPH等相关学科)
博士后 (方向：病原学、微生物组、生物信息学等相关学科)

 

【近年论文代表作】

  • Y Zhai, X Li, J Lu, C Guo#，The gut microbiome in post-COVID syndrome patients，The Innovation Medicine 3 (2), 2025; 100123-1-100123-12
  • W Mao, J Wang, T Li, J Wu, J Wang, S Wen, J Huang, Y Shi, K Zheng, .. C Guo#,  Hybrid Capture-Based Sequencing Enables Highly Sensitive Zoonotic Virus Detection Within the One Health Framework, Pathogens, 2025; 14 (3), 264
  • S Zhang, C Zhao, G Liu, L Guo, R Zhang, J Yan, J He, C Guo#, Monitoring of pathogens carried by imported flies and cockroaches at shenzhen ports, Tropical Medicine and Infectious Disease, 2025; 10 (2), 57

  • C. Guo, J. Y. Wu. Pathogen Discovery in the Post-COVID Era. Pathogens, 2024, 13(1)

  • X Li, C Liao, J Wu, B Yi, R Zha, Q Deng, J Xu, C Guo#, J Lu#, Distinct serum exosomal miRNA profiles detected in acute and asymptomatic dengue infections: A community-based study in Baiyun District, Guangzhou, Heliyon 10 (10)

  • C. Guo, X. Che, T. Briese, A. Ranjan, O. Allicock, R. A. Yates et al. Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS. Cell Host Microbe, 2023, 31(2): 288-304.e8

  • C. Guo, B. Yi, J. Wu, J. Lu. The microbiome in post-acute infection syndrome (PAIS). Computational and structural biotechnology journal, 2023, 21: 3904-3911

  • Q. Wu*, C. Guo*, X. K. Li, B. Y. Yi, Q. L. Li, Z. M. Guo et al. A meta-transcriptomic study of mosquito virome and blood feeding patterns at the human-animal-environment interface in Guangdong Province, China. One Health , 2023, 16: 100493

  • X. Cheng, Y. Zhang, Y. Li, Q. Wu, J. Wu, S. K. Park, C. Guo#, J. Lu#. Meta-analysis of 16S rRNA microbial data identified alterations of the gut microbiota in COVID-19 patients during the acute and recovery phases. BMC Microbiology, 2022, 22(1): 1-13

  • Y. Wu, X. Cheng, G. Jiang, H. Tang, S. Ming, L. Tang, C. Guo#, H. Shan#, X. Huang#. Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization. NPJ biofilms and microbiomes, 2021, 7(1): 61

  • J. Y. Wu*, C. Guo*, Y. Xia, H. M. Bao, Y. S. Zhu, Z. M. Guo et al. Genomic characterization of Wenzhou mammarenavirus detected in wild rodents in Guangzhou City, China. One health (Amsterdam, Netherlands), 2021, 13: 100273

  • J. Wang*, C. Guo*, L. Cai, C. Liao, H. Yi, Q. Li et al. Pre-Existing Cross-Reactive Antibody Responses Do Not Significantly Impact Inactivated COVID-19 Vaccine-Induced Neutralization. Frontiers in immunology, 2021, 12: 772511

  • J. Y. Wu*, Y. S. Zhu*, C. Guo*, Y. Xia, Z. M. Guo, Q. L. Li et al. A Comparative Study of Associated Microbiota Between Pig Farm and Pig Slaughterhouse in Guangdong, China. Current microbiology, 2020, 77(11): 3310-3320

  •  Y. Wu*, C. Guo*, L. Tang, Z. Hong, J. Zhou, X. Dong et al. Prolonged presence of SARS-CoV-2 viral RNA in faecal samples. The lancet. Gastroenterology & hepatology, 2020, 5(5): 434-435

  •  M. Allicock*, C. Guo*, A. C. Uhlemann, S. Whittier, L. V Chauhan, J. Garcia et al. BacCapSeq: a Platform for Diagnosis and Characterization of Bacterial Infections. mBio, 2018, 9(5)